Nate is currently facing a difficult situation in his Baldur's Gate 3 run, having lost the duegar boat fight and with an unsaved file from the middle of the fight with Astarion and Wyll dead, Karlach downed, and Shadowheart with only 7HP. The first and most straightforward solution for Nate would be to use a save editor to load a previous save file before the boat fight. However, finding a save file that is prior to the boat fight and that has all the characters alive and well might be challenging. The second option for Nate would be to load the save file that he has and try to manually play through the fight again, this time making sure to heal the characters after the fight against the slave hunter. This option would require a lot of patience and careful gameplay, as it is likely that the characters will take significant damage in the fight.
The third option for Nate would be to start a new game with the same origin and builds and try to recreate the run. This option would allow Nate to experience the story and builds again, but it would also require a significant amount of time and effort. Finally, Nate could try to contact the developers of Baldur's Gate 3 to see if they could help him out. This option is highly unlikely, but it is worth a shot for a player who has already sunk thirty hours into a run.
Overall, Nate has a few options to choose from to continue his Baldur's Gate 3 run. He could either use a save editor, replay the fight carefully, start a new game, or contact the developers for help. Whichever option he chooses, he should be prepared for a challenging and time-consuming experience.
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